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R&D Center

Located in Shandong Jinan Pharmacetical Valley Park, our R&D center now has more than 30 R&D staffs, including 5 PhD&11 masters, all of them have rich R&D experience; moreover, we found a 1,000 square meters of laboratory in Jinan city of Shandong province, with synthetic laboratory, analytical laboratoriy, Salt formation and crystal form laboratory, etc.; There are complete supporting equipment in laboratory, including high-performance liquid chromatography, liquid chromatograph/mass spectrometer, high and low temperature one machine, 50L and 100L reactor, 100L hydrogenation reactor and other equipment.

It is mainly responsible for the connection of synthesis process of raw materials and intermediates, connection of customized products, as well as the transformation&engagement of laboratory technology to pilot process.

 

Products list

Main products:AfatinibAfatinib dimaleate7-Fluoro-6-nitro-4-hydroxyquinazolineN-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinaminen-(3-chloro-4-fluorophenyl)-6-nitro-7-(((3s)-tetrahydro-3-furanyl)oxy)-4-quinazolinamineN4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine(s)-(+)-3-hydroxytetrahydrofuran;(s)-(+)-tetrahydro-3-furanoltrans-4-dimethylaminocrotonic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochlorideIdelalisib(CAL-101)[(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-oneboc-l-2-aminobutyric acid2-fluoro-6-nitro-n-phenylbenzamide2-amino-5-fluoro-n-phenylbenzamide2-aMino-6-fluoro-N-phenylbenzaMide hydrochlorideTedizolid phosphateTedizolidn-(3-fluoro-4-(6-(2-methyl-2h-tetrazol-5-yl)-3-pyridinyl)phenyl)carbamic acid phenylmethyl ester5-bromo-2-(2-methyl-2h-tetrazol-5-yl)pyridine;2-(2-methyl-5-tetrazolyl)-5-bromopyridine(5r)-3-(4-bromo-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one2-(2-methyl-2h-tetrazol-5-yl)pyridine-5-boronic acid pinacol ester;2-(2-methyl-2h-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineNintedanib (BIBF 1120)Nintedanib Ethanesulfonate Saltmethyl 2-oxoindole-6-carboxylate;6-methoxycarbonyl-2-oxindole; oxindole-6-carboxylic acid methyl esterN-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamideN-Methyl-4-nitroaniline(3e)-2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-1h-indole-6-carboxylic acid methyl estertrimethyl orthobenzoateLesinurad(RDEA594)3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-5-thiol4-Cyclopropyl-1-naphthalenamine hydrochloride (1:1)1-cyclopropyl-4-isothiocyanatonaphthalene4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thioneMethyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetateLenvatinib (E7080)Lenvatinib Mesylate4-chloro-7-methoxyquinoline-6-carboxamide1,4-dihydro-7-methoxy-4-oxo-6-quinolinecarboxylic acid methyl esterMethyl 4-chloro-7-methoxyquinoline-6-carboxylate4-amino-3-chlorophenolIbrutinib(PCI-32765)(r)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1h-pyrazolo(3,4-d)pyrimidin-4-amine3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-4-amine3-amino-4-cyano-5-(4-phenoxyphenyl)pyrazole(S)-1-Boc-3-hydroxypiperidinePalbociclib (PD0332991)tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-oneMacitentan4,6-dichloro-5-(4-bromophenyl)pyrimidinen-propylsulfamide;propylsulfamiden-propyl-sulfamide potassium saltn-propylsulfamide sodium saltn1-(2-(dimethylamino)ethyl)-5-methoxy-n1-methyl-n4-(4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl)-1,2,4-benzenetriamineN1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-2-nitro-1,4-benzenediaminen-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1h-indol-3-yl)-2-pyrimidinamine4-fluoro-2-methoxy-5-nitroaniline3-(2-chloro-4-pyrimidinyl)-1-methyl-1h-indoleNeratinib(HKI-272)3-Chloro-4-[(pyridin-2-yl)methyloxy]anilinen-(4-chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide4-[4-[(2-Pyridyl)methoxy]-3-chloroanilino]-6-amino-3-cyano-7-ethoxyquinolinePazopanibPazopanib HCL3-Methyl-6-nitroindazole2,3-Dimethyl-6-nitro-2H-indazole2,3-Dimethyl-6-amino-2H-indazole2,3-Dimethyl-2H-indazol-6-amine hydrochlorideCeritinib2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine5-Methyl-2-(1-methylethoxy)-4-(4-piperidinyl)benzenamine hydrochlorideTAK-438;Vonoprazan fumarate3-Pyridinesulfonyl chloride5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehydeOlaparib(AZD2281)1-(Cyclopropylcarbonyl)piperazine hydrochlorideTAS 102Trifluorothymine6-(Chloromethyl)uracil3,4-Dihydro-2H-pyrrol-5-amine hydrochlorideLapatinibLapatinib ditosylate monohydrate3-Chloro-4-(3-fluorobenzyloxy)aniline4-Chloro-6-iodoquinazoline2-Aminoethylmethylsulfone hydrochlorideRociletinib(CO-1686)4-(4-Acetyl-1-piperazinyl)-2-(methyloxy)aniline(3-Aminophenyl)carbamic acid tert-butyl ester2,4-Dichloro-5-trifluoromethylpyrimidineRucaparibRucaparib camsylateRucaparib phosphate2-Bromo-8-fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one6-Fluoro-1H-indole-4-carboxylic acid methyl estern-(2-oxoethyl)phthalimide5-Fluoro-2-methyl-3-nitrobenzoic acid methyl esterEzetimibeN-(4-(Benzyloxy)benzylidene)-4-fluoroaniline1-(Cyclopropylmethyl)piperazineN-(2,5-Dichlorobenzoyl)glycineABT-199 (GDC-0199)Venetoclax2-[(1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid1-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazine3-Nitro-4-[[(tetrahydropyran-4-yl)methyl]amino]benzenesulfonamideMethyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-fluorobenzoate1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde5-Bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridinetert-Butyl 4-bromo-2-fluorobenzoate4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde